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Breast cancer cells spread during sleep
Circulating breast cancer cells that later form metastases mainly arise during a person’s sleep phase, a new study shows. To date, cancer research has not paid much attention to the question of when...
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‘Hot spots’ may improve breast cancer mapping
Using a new technique, researchers have found tiny and previously undetectable “hot spots” of extremely high stiffness inside aggressive and invasive breast cancer tumors. Their findings suggest, for...
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Genes may help predict prostate cancer metastasis risk
Researchers have discovered human gene markers that work together to cause metastatic prostate cancer– cancer that spreads beyond the prostate. In their new study in Nature Cancer, researchers examined...
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Key protein tweak may stop cancer’s spread
The new discovery of a key protein behind cancer relapse and progression could lead to new therapies, researchers report. In a their new study, the researchers found that the MBNL1 protein acts a...
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Switch ‘turns off’ breast cancer metastasis in mice
Researchers have identified a gene that causes an aggressive form of breast cancer to rapidly grow in animal models. More importantly, they have also discovered a way to “turn it off” and inhibit...
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Can 1 gene unlock the mystery of cancer metastasis?
Our own pre-existing genetics can promote cancer metastasis, researchers report. Sometimes cancer stays put, but often it metastasizes, spreading to new locations in the body. Scientists have long...
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Protein signals if non-small cell lung cancer will spread
Researchers have identified a protein on tumor-derived extracellular vesicles that indicates if a non-small cell lung cancer tumor is likely to metastasize, according to a new study. Non-small cell...
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Breast cancer cells shift metabolism to spread
Breast cancer cells can shift their metabolism to metastasize, according to a new study. Instead of cycling sugar (glucose) for energy, the cells preferentially use mitochondrial metabolism,...
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Cancer’s ‘addiction’ could be a way to defeat it
Some cancers are hooked on particular molecules. New research with gastric cancer “organoids” lends credence to the idea that denying cancer these compounds could kill it. Elizabeth Vincan’s research...
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‘Decoy’ implants could replace dangerous cancer biopsies
Taking samples from a tiny “decoy” implant just beneath the skin could replace invasive procedures to biopsy tissue from cancer-tainted organs, new research in mice shows. These devices have a knack...
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Team discovers tiny ‘bike courier’ vesicle in cells
A previously unknown kind of vesicle delivers proteins in cells like a bike courier in heavy traffic, researchers find. The discovery could shed light on the mechanisms that let cells spread in...
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Collagen fiber length lets cells stream away quickly
Collagen fiber length within the body may be a key overlooked parameter that some normal cells use to become invasive, research finds. Collagen is the most abundant protein in mammals, making up skin,...
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Stem cell therapy treats bone metastases but saves bone
A new therapeutic treatment uses engineered stem cells to target and kill cancer bone metastases while preserving the bone, a study with mice shows. The approach equips engineered mesenchymal stem...
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Nanotech injection nabs cancer cells on the run
Cellular soldiers created using the body’s own defenses can track down and kill cancer cells that escape during surgeries, researchers report. This could prevent metastasis and save lives, particularly...
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Invading cells bulge to get through barriers
Scientists have figured out how invasive cells deploy a trick to break through tissues. The findings may help explain how cancer spreads to other parts of the body. In a new study, 3D time-lapse...
View ArticleTo stop cancer’s spread, break its ‘legs’
Cancer cells most often kill by crawling away from their original tumors to later re-root in vital parts of the body in a process called metastasis. Bristly leg-like protrusions that cover cancer cells...
View ArticleSquished cancer cells break free from the crowd
Scientists now know the biochemical signal that tells crowded cancer cells to break away from tumors and start the deadly migration called metastasis. They also discovered that two existing drugs used...
View ArticleCompound cuts melanoma’s spread by up to 90%
Scientists have discovered that a chemical compound—and potential new drug—reduces the spread of melanoma cells by up to 90 percent. The synthetic, small-molecule drug compound goes after a gene’s...
View ArticleThese genes may take fight out of sarcoma cells
Scientists have identified a set of genes that may make sarcoma cells less aggressive. They hope the discovery will lead to new therapeutic approaches to fight metastatic cancers. The work, which...
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Cancer cells travel in packs to survive and spread
Cancer cells rarely spread on their own, preferring to travel in groups from their original tumor site, a new study with mice shows. Collaboration seems to increase their collective chance of surviving...
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